Genes Linked To Schizophrenia, Bipolar Disorder

Broad sweeps of the human genome have exposed genetic mutations that boost the risk of the devastating yet baffling diseases of schizophrenia and bipolar disorder, according to two studies published Sunday.

The independent studies, each conducted by a consortium of about 200 scientists, also found significant genetic overlap between the debilitating mental disorders.

Schizophrenia patients typically hear voices that are not real, tend toward paranoia and suffer from disorganized speech and thinking. The condition is thought to affect about one percent of adults worldwide.

Previously known as manic depression, bipolar disorder is characterised by hard-to-control mood swings that veer back-and-forth between depression and euphoria, and afflicts a similar percentage of the population.The biological profile of both conditions remain almost entirely unknown. Doctors seek to hold them in check with powerful drugs.Scientists have long observed that each syndromes tends to run in families, suggesting a powerful inherited component.But early hopes of finding a single-gene culprit swiftly faded, giving way to the realization that - to the extentblame is probably spread across dozens, maybe even hundreds variants.wide comparisons made possible by gains in computing power involve sweeps of tens of thousands of individual genetic codes from patients and otherwise healthy counterpartsBut so far only a handful of suspects have been found that, at best, account for about 30 percent of the heritable component of schizophrenia.Nailing down genetic drivers is madeeven harder by uncertainty as to whether schizophrenia and bipolar - defined by a varying constellation of symptoms - are single or multiple diseases.